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Kinetic study of the reaction of pyridoxal 5′-phosphate with hydrazine

✍ Scribed by Gerardo R. Echevarrı́a Gorostidi; Andrea Basagoitı́a; José G. Santos Blanco; Francisco Garcı́a Blanco

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
114 KB
Volume
129
Category
Article
ISSN
1381-1169

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✦ Synopsis

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. The kinetics of the reaction between pyridoxal 5 -phosphate PLP and hydrazine in aqueous solution at a variable pH and a constant strength of 0.1 M was studied spectrophotometrically. The rate constants of formation and hydrolysis of the resulting Schiff base and its stability were also determined in a wide range of pH. A comparison of the formation rate constants with those for the models of PLP with n-hexylamine and with poly-L-lysine revealed that hydrazine formed Schiff base more quickly than lysine below pH 7 and than n-hexylamine below pH 8. The reactivity shows the sequence poly-L-lysine) n-hexylamine) hydrazine in whole studied range of pH. Schiff bases formed by hydrazine with PLP are more stable than the ones formed by n-hexylamine in the pH range studied and more stable than the formed by poly-L-lysine at pH -7.0. q 1998 Elsevier Science B.V.

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