Kinetic study of the interaction of adenosine 5′-monophosphate with diaqua (2-hydrazinopyridine) palladium(II) in aqueous medium

✍ Scribed by Mohamed M. Khattab; Ahmed A. Soliman; Wolfgang Linert

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 384 KB
• Volume: 42
• Category: Article
• ISSN: 0538-8066
• DOI: 10.1002/kin.20470

✦ Synopsis

Abstract

The interaction of the palladium(II) complex [Pd(hzpy)(H~2~O)~2~]^2+^, where hzpy is 2‐hydrazinopyridine, with purine nucleoside adenosine 5′‐monophosphate (5′‐AMP) was studied kinetically under pseudo‐first‐order conditions, using stopped‐flow techniques. The reaction was found to take place in two consecutive reaction steps, which are both dependent on the actual 5′‐AMP concentration. The activation parameters for the two reaction steps, i.e. ΔH = 32 ±2 kJ mol^−1^, ΔS = −168 ±7 J K^−1^ mol^−1^, and ΔH = 28 ± 1 kJ mol^−1^, ΔS = −126 ± 5 J K^−1^ mol^−1^, respectively, were evaluated and suggested an associative mode of activation for both substitution processes. The stability constants and the associated speciation diagram of the complexes were also determined potentiometrically. The isolated solid complex was characterized by C, H, and N elemental analyses, IR, magnetic, and molar conductance measurements. © 2009 Wiley Periodicals, Inc. Int J Chem Kinet 42: 132–142, 2010