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Kinetic studies on the conversion of prostaglandin endoperoxide PGH2 by thromboxane synthase

✍ Scribed by M.W. Anderson; D.J. Crutchley; B.E. Tainer; T.E. Eling

Book ID
119048742
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
344 KB
Volume
16
Category
Article
ISSN
0090-6980

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Synthesis of a new prostaglandin endoper
Synthesis of a new prostaglandin endoperoxide (PGH2) analog and its function as an inhibitor of the biosynthesis of thromboxane A2 (TBXA2)
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Since the discovery that the prostaglandin endoperoxides PGG2 and PGH2 are convertedenzymically to the highly unstable but biologically potent substance thromboxane A2 l-3 by a relatively straightforward mechanism, it has been clear that various synthetic analogs of the PG endoperoxides would be of