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Kinetic studies on general base-catalyzed cleavage of phthalimide (PTH) in 2-hydroxyethylamine and 2-methoxyethylamine buffers

✍ Scribed by M. Niyaz Khan

Book ID: 102653035
Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 547 KB
Volume: 28
Category: Article
ISSN: 0538-8066
DOI: 10.1002/(sici)1097-4601(1996)28:6<421::aid-kin4>3.0.co;2-x

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✦ Synopsis

Kinetic studies on the nucleophilic cleavage of phthalirnide [ PTH) in buffers of 2-hydroxyethylarnine and 2-rnethoxyethylarnine reveal nonlinear plots of k, vs I Bufl, (at constant pH)

where k, and IBuf], represent apparent second-order rate constant and total arnine buffer concentration, respectively. The nonlinear variation of k, against [BuflT is attributed to the occurrence of a stepwise mechanism in the aminolysis of PTH Intermolecular general base catalysis is detected in the reactions of both arnines with nonionized PTH (SH) only within the pH range of the present study 0 1996 john Wiley &Sons, Inc

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