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Kinetic mechanism of streptomycin adenylyltransferase from a recombinantEscherichia coli

✍ Scribed by Snehasis Jana; J. K. Deb

Publisher
Springer Netherlands
Year
2005
Tongue
English
Weight
349 KB
Volume
27
Category
Article
ISSN
0141-5492

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tRNA-guanine transglycosylase (TGT) is a key enzyme in the post-transcriptional modification of certain tRNAs with the pyrrolopyrimidine base queuine. TGT is required for pathogenicity in Shigella flexneri, a human pathogen, and therefore is potentially a novel antibacterial target. Previous work ha