A mathematical technique for estimating the kinetic parameters that control patient response to oral anticoagulant administration is presented. The technique utilizes routinely obtained and recorded data such as anticoagulant dose regimen and prothrombin times. It is possible to apply during any sta
Kinetic effects of multiple oral doses of acetaminophen on a single oral dose of lamotrigine
β Scribed by Depot, Michelle; Robert Powell, J; Messenheimer, John A; Cloutier, Gilles; Dalton, Michael J
- Book ID
- 109844780
- Publisher
- Nature Publishing Group
- Year
- 1990
- Tongue
- English
- Weight
- 670 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0009-9236
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## Abstract The __in vivo__ characteristics of two formulations of a recently developed controlledβrelease system, the Gradient Matrix System (GMSβ1 and GMSβ2), with acetaminophen as a model drug compound have been determined in healthy volunteers both after separate singleβ and multipleβdose admin