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Kinetic Considerations for the Quantitative Assessment of Efflux Activity and Inhibition: Implications for Understanding and Predicting the Effects of Efflux Inhibition

✍ Scribed by J. Cory Kalvass; Gary M. Pollack


Publisher
Springer US
Year
2006
Tongue
English
Weight
481 KB
Volume
24
Category
Article
ISSN
0724-8741

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Site. -Depending on the reaction time, indan-1-ones (III) and inden-1-ones (V) are prepared. They are further used to study the active binding site of human aromatase inhibitors. Two compounds (Vb) and (Vc) are good inhibitors of human aromatase whereas they weakly inhibit the equine enzyme.