Kinetic aspects of the enantiospecific reduction of sodium 3-fluoropyruvate catalyzed by rabbit muscle l-lactate dehydrogenase: Production of homochiral (R)-3-fluorolactic acid methyl ester

Enzymatic laboratory scale production of

Enzymatic laboratory scale production of homochiral (R)-3-fluorolactic acid methyl ester via enantiospecific reduction of sodium fluoropyruvate catalyzed by rabbit muscle l-lactate dehydrogenase (l-LDH)

✍ L.P.B. Gonçalves; O.A.C. Antunes; G.F. Pinto; E.G. Oestreicher 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 279 KB

In the present work a simple laboratory procedure for the synthesis of (R)-3-Fluomlactic Methyl Ester(l) is described. A coupled enzymatic system formed by tacit muscle L-lactate dehydrogcnase (L-LDH), horse liver alcohol dehydrogenase (HLADH), fluoropyruvic acid sodium salt, NAD + and cis-l,2-bis(h