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Kinetic and Thermodynamic Characterization of the Common Polymorphic Variants of Human Methionine Synthase Reductase †

✍ Scribed by Olteanu, Horatiu; Wolthers, Kirsten R.; Munro, Andrew W.; Scrutton, Nigel S.; Banerjee, Ruma


Book ID
120175187
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
198 KB
Volume
43
Category
Article
ISSN
0006-2960

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Polymorphic background of methionine syn
✍ Carmen Gherasim; David S. Rosenblatt; Ruma Banerjee 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 192 KB

## Communicated by Jan Kraus Methionine synthase reductase (MTRR) is the locus of the cblE class of inborn errors of cobalamin metabolism that is characterized by megaloblastic anemia and homocystinuria. Two highly prevalent SNPs, c.66A4G (p.Ile22Met) and c.524C4T (p.Ser175Leu), are found in the M