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Kinetic and Structural Characteristics of the Inhibition of Enoyl (Acyl Carrier Protein) Reductase by Triclosan ‡

✍ Scribed by Ward, Walter H. J.; Holdgate, Geoffrey A.; Rowsell, Siân; McLean, Estelle G.; Pauptit, Richard A.; Clayton, Edward; Nichols, Wright W.; Colls, Jeremy G.; Minshull, Claire A.; Jude, David A.; Mistry, Anil; Timms, David; Camble, Roger; Hales, Neil J.; Britton, Carolyn J.; Taylor, Ian W. F.


Book ID
120544236
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
229 KB
Volume
38
Category
Article
ISSN
0006-2960

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## Abstract Enoyl acyl carrier protein reductase (ENR), which catalyzes the final and rate limiting step of fatty acid elongation, has been validated as a potential drug target. Triclosan is known to be an effective inhibitor for this enzyme. We mutated the substrate binding site residue Ala372 of