Kinetic and Structural Characteristics of the Inhibition of Enoyl (Acyl Carrier Protein) Reductase by Triclosan ‡
✍ Scribed by Ward, Walter H. J.; Holdgate, Geoffrey A.; Rowsell, Siân; McLean, Estelle G.; Pauptit, Richard A.; Clayton, Edward; Nichols, Wright W.; Colls, Jeremy G.; Minshull, Claire A.; Jude, David A.; Mistry, Anil; Timms, David; Camble, Roger; Hales, Neil J.; Britton, Carolyn J.; Taylor, Ian W. F.
- Book ID
- 120544236
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 229 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0006-2960
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## Abstract Enoyl acyl carrier protein reductase (ENR), which catalyzes the final and rate limiting step of fatty acid elongation, has been validated as a potential drug target. Triclosan is known to be an effective inhibitor for this enzyme. We mutated the substrate binding site residue Ala372 of
## Abstract PfENR A372M mutant showing a different conformation of Methionine compared to the Met206 of EcENR by Koustav Maity et al., pp 30–41.