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Kinetic and equilibrium studies of the ribonuclease-catalyzed hydrolysis of uridine 2',3'-cyclic phosphate

โœ Scribed by Del Rosario, Ernesto J.; Hammes, Gordon G.


Book ID
126919607
Publisher
American Chemical Society
Year
1969
Tongue
English
Weight
594 KB
Volume
8
Category
Article
ISSN
0006-2960

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The reactions of a ribonuclease model substrate, the compound uridine-3'-p-nitrophenyl phosphate, have been examined using heavy-atom isotope effects and stereochemical analysis. The cyclization of this compound is subject to catalysis by general base (by imidazole buffer), specific base (by carbona