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Kinetic analysis of the dual catalysis by proline in the asymmetric intramolecular aldol reaction

โœ Scribed by Claude Agami; Catherine Puchot


Book ID
103692373
Publisher
Elsevier Science
Year
1986
Weight
141 KB
Volume
38
Category
Article
ISSN
0304-5102

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Theoretical evidence now suggests that the mechanism of the longdebated Hajos-Parrish-Eder-Sauer-Wiechert reaction, the prototype for asymmetric organocatalytic reactions, involves a proline enamine intermediate (center) which undergoes a concerted aldol cyclization with proton transfer. For more de