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Kinase domain mutation of MLK4 gene is uncommon in gastric and hepatocellular carcinomas

✍ Scribed by Y.H. Soung; J.W. Lee; S.Y. Kim; S.W. Nam; W.S. Park; J.Y. Lee; N.J. Yoo; S.H. Lee

Book ID
119228081
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
53 KB
Volume
38
Category
Article
ISSN
1590-8658

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To clarify the clinical significance of the mutation of p53 gene in hepatocellular carcinoma (HCC), 90 resected specimens from Japanese patients were assayed using a polymerase chain reaction-single strand conformation polymorphism (PCRSSCP) analysis. p53 mutations were detected in 25 cases (27.8%)