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Ki67 and doublecortin positive cells in the human prefrontal cortices of normal aging and vascular dementia

✍ Scribed by Gang Lu; Sen Mun Wai; W.S. Poon; D.T. Yew

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 149 KB
Volume: 68
Category: Article
ISSN: 1059-910X
DOI: 10.1002/jemt.20242

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✦ Synopsis

Immunohistochemical localizing of the proliferation of Ki67 nuclei and doublecortin positive cells were performed in the prefrontal cortex of normal aged and vascular dementia (multiple infarct dementia) patients. Positive Ki67 nuclei and doublecortin positive cells were observed in both groups, with slightly higher density in the prefrontal cortex of vascular dementia. When the Ki67 sites were superimposed with the neuronal specific enolase localizations, only about 5% of the cells was doubly labeled, indicating few proliferating cells were neurons. This percentage did not vary between specimens of normal aging and those of vascular dementia.

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