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KF17837 ((E)-8-(3,4-dimethoxystyryl)-1,3-dipropyl-7-methylxanthine) a potent and selective adenosine A2 receptor antagonist

✍ Scribed by Hiromi Nonaka; Michio Ichimura; Masami Takeda; Yoshiko Nonaka; Jyunichi Shimada; Fumio Suzuki; Kazuo Yamaguchi; Hiroshi Kase


Book ID
113398757
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
678 KB
Volume
267
Category
Article
ISSN
0922-4106

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Tritium-labelled 8-cyclopentyl-3-(3-fluo
✍ Marcus H. Holschbach; Walter Wutz; Manfred SchΓΌller; Dirk Bier; H.H. Coenen πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 French βš– 97 KB

The reduction of 1-allyl-8-cyclopentyl-3-(3-fluoropropyl)xanthine, 7, with tritium gas catalyzed by 10% Pd-C gave 8-cyclopentyl-3-(3-fluoropropyl)-1-[2,3-3 H]propylxanthine ([ 3 H]CPFPX), 8\*, a potent and selective antagonist for the A 1 adenosine receptor (A 1 AR). The synthesis of 7 proceeded fro