An 11C-labeled selective adenosine A2A antagonist, (E)-8-(3,4-dimethoxystyryl)-1,3-dipropyl-7-[11C]-methylxanthine ([11C]KF17837), was prepared by reaction of (E)-8-(3,4-dimethoxystyryl)-1,3-dipropylxanthine and [11C]methyl iodide with decay-corrected radiochemical yield of 19-50%, radiochemical pur
KF17837: A novel selective adenosine A2A receptor antagonist with anticataleptic activity
β Scribed by Tomoyuki Kanda; Shizuo Shiozaki; Junichi Shimada; Fumio Suzuki; Joji Nakamura
- Book ID
- 115889801
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 1004 KB
- Volume
- 256
- Category
- Article
- ISSN
- 0014-2999
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The recent discovery of selective antagonists for the A 2A adenosine receptors has been of great help to further research in this field. One compound, SCH 58261, 5-amino-7-(Ξ²-phenylethyl)-2-(8furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine, is playing a key part in a variety of studies. This r