𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Key role of glutamic acid for the cytotoxic activity of the cyclotide cycloviolacin O2

✍ Scribed by A. Herrmann; E. Svangård; P. Claeson; J. Gullbo; L. Bohlin; U. Göransson


Publisher
Springer
Year
2006
Tongue
English
Weight
234 KB
Volume
63
Category
Article
ISSN
1420-682X

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


The key role of hydroxylation for the cy
✍ Peter Hilgard; Norbert Brock 📂 Article 📅 1984 🏛 Springer US 🌐 English ⚖ 164 KB

The "pro-drug" cyclophosphamide (CP) is activated by liver "mixed function" hydroxylases to 4-hydroxy-cyclophosphamide (4-OH-CP), which represents the cytostatically active principle. Since the primary metabolite 4-OH-CP retains all the specific pharmacological properties of the parent compound with

An efficient synthesis of a key intermed
✍ Qingping Tian; Naresh K Nayyar; Srinivasan Babu; Lijian Chen; Junhua Tao; Steven 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 65 KB

An efficient synthetic route to a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 has been developed employing a key asymmetric dianionic cyanomethylation of N-Boc-L-(+)-glutamic acid dimethyl ester. This methodology enables the preparation of this compound in kilogr