Maturity onset diabetes of the young (MODY) is a genetically heterogeneous form of type 2 diabetes that is characterized by autosomal dominant inheritance, onset in early adulthood and a primary defect in insulin secretion. Mutations in at least six genes have been shown to underlie MODY, including
Keeping diabetes in the family: lessons from a family with HNF-1α MODY
✍ Scribed by MP Selwood; KR Owen
- Publisher
- Maney Publishing
- Year
- 2008
- Tongue
- English
- Weight
- 771 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1551-7853
- DOI
- 10.1002/edn.113
No coin nor oath required. For personal study only.
✦ Synopsis
The Metabolic Syndrome: micro and macro facets • Should we redefine measurements of blood glucose control and categories
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Mutations in the transcription factor hepatocyte nuclear factor-1a (HNF-1a; gene symbol TCF1) cause maturity-onset diabetes of the young type 3 (MODY3), a form of diabetes mellitus characterized by autosomal dominant inheritance, early onset, and pancreatic b-cell dysfunction. Recent genetic studies
Maturity-onset diabetes of the young is a genetically heterogenous autosomal dominant form of diabetes mellitus, characterized by an early age at onset and a primary defect in beta-cell function. Forty families with a clinical presentation suggestive of MODY were screened for the most common MODY su
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