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KATP Channel Openers: Structure—Activity Relationships and Therapeutic Potential

✍ Scribed by Raimund Mannhold

Book ID
101952835
Publisher
John Wiley and Sons
Year
2004
Weight
49 KB
Volume
35
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

For Abstract see ChemInform Abstract in Full Text.

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ATP-sensitive potassium channels (K ATP channels) are heteromeric complexes of poreforming inwardly rectifying potassium channel subunits and regulatory sulfonylurea receptor subunits. K ATP channels were identified in a variety of tissues including muscle cells, pancreatic b-cells, and various neur

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Synthesis and Structure-Activity Relationships of Thienylcyanoguanidine Derivatives as Potassium Channel Openers. -A series of thienylcyanoguanidine derivatives [cf. (V), (X), (XIII)] is synthesized and evaluated for their smooth muscle relaxation activity in vitro. Among the newly synthesized comp