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Kalopanaxsaponin A induces apoptosis in human leukemia U937 cells through extracellular Ca2+ influx and caspase-8 dependent pathways

✍ Scribed by Jung-Hye Choi; Heon-Woo Lee; Hee-Juhn Park; Sung-Hoon Kim; Kyung-Tae Lee


Book ID
116462576
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
658 KB
Volume
46
Category
Article
ISSN
0278-6915

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## Abstract Exogenous Ξ²~2~‐microglobulin (Ξ²~2~m) induces significant apoptosis in the CCRF‐HSB‐2 human lymphoblastic leukemia cell line as detected by DNA fragmentation, DAPI staining and annexin V binding assay. Ξ²~2~m treatment induced the release of cytochrome c and apoptosis‐inducing factor (AIF