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K-ras and p16INK4Aalterations in sputum of NSCLC patients and in heavy asymptomatic chronic smokers

โœ Scribed by Destro, A; Bianchi, P; Alloisio, M; Laghi, L; Di Gioia, S; Malesci, A; Cariboni, U; Gribaudi, G; Bulfamante, G; Marchetti, A; Bosari, S; Infante, M; Ravasi, G; Roncalli, M


Book ID
119318825
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
323 KB
Volume
44
Category
Article
ISSN
0169-5002

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K-ras mutation in sputum of patients wit
โœ Ze'ev Ronai; Marina S. Yabubovskaya; Edith Zhang; Gennady A. Belitsky ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 493 KB ๐Ÿ‘ 2 views

K-ras mutation appears in about 60% of patients with non-small-cell lung cancer (NSCLC). This freqLency and its presence in normal appearing tissues point to the potential of ras oncogene mutation to serve as a good biomarker. Using enriched PCR (EPCR), which enables the detection of one mutant alle