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K+-efflux modulation of cisplatin-induced apoptosis and cytotoxicity to cultured mesothelioma cells

✍ Scribed by L. Marklund; R. Henriksson; K. Grankvist

Book ID
117667366
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
116 KB
Volume
35
Category
Article
ISSN
0959-8049

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Cisplatin-induced apoptosis of mesotheli
Cisplatin-induced apoptosis of mesothelioma cells is affected by potassium ion flux modulator amphotericin B and bumetanide
✍ Linda Marklund; Roger Henriksson; Kjell Grankvist πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 French βš– 121 KB

Chemotherapeutic anti-cancer drugs induce cell death by the process of apoptosis. Efflux of potassium ions (K(+)) is necessary for cell volume reduction during apoptosis and increased inward pumping of K(+) thus counteracts apoptosis. Potassium flux modulation could therefore interact with apoptosis