Cisplatin-induced apoptosis of mesothelioma cells is affected by potassium ion flux modulator amphotericin b and bumetanide

Cisplatin-induced apoptosis of mesotheli

Cisplatin-induced apoptosis of mesothelioma cells is affected by potassium ion flux modulator amphotericin B and bumetanide

✍ Linda Marklund; Roger Henriksson; Kjell Grankvist 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 121 KB

Chemotherapeutic anti-cancer drugs induce cell death by the process of apoptosis. Efflux of potassium ions (K(+)) is necessary for cell volume reduction during apoptosis and increased inward pumping of K(+) thus counteracts apoptosis. Potassium flux modulation could therefore interact with apoptosis