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JNK-independent Pathways of Acetaminophen-induced Hepatic Injury in Cyclophilin D-deficient Mice

โœ Scribed by Amanda LoGuidice; Urs A. Boelsterli

Book ID
113631570
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
387 KB
Volume
49
Category
Article
ISSN
0891-5849

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๐Ÿ“œ SIMILAR VOLUMES

Acetaminophen overdose-induced liver inj
Acetaminophen overdose-induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D-regulated permeability transition
โœ Amanda LoGuidice; Urs A. Boelsterli ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 613 KB

Acetaminophen (APAP) is safe at therapeutic dosage but can cause severe hepatotoxicity if used at overdose. The mechanisms of injury are not yet fully understood, but previous reports had suggested that the mitochondrial permeability transition (mPT) may be involved in triggering hepatocellular necr