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Inhibitory effect of cold stress against acetaminophen-induced hepatic injury in B6C3F1 and ICR mice

โœ Scribed by Hiro-aki Yamamoto; Keiji Fujii; Toshiyuki Hayakawa


Book ID
118411862
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
492 KB
Volume
81
Category
Article
ISSN
0378-4274

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In studies designed to simulate a clinical observation in which an individual became tolerant to normally lethal doses of acetaminophen (APAP), mice were pretreated with increasing doses of APAP for 8 days and challenged on day 9 with normally supralethal doses of APAP. These animals developed minim