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JC virus DNA in healthy brain tissue: A challenge for progressive multifocal leukoencephalopathy diagnosis

✍ Scribed by Daniele Focosi; Richard Eric Kast; Fabrizio Maggi; Luca Ceccherini-Nelli; Mario Petrini


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
42 KB
Volume
65
Category
Article
ISSN
0364-5134

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✍ Dawn McGuire; Steven Barhite; Harry Hollander; Dr Michael Miles πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 553 KB

Progressive multifocal leukoencephalopathy (PML) is a lytic infection of oligodendrocytes by the human papovavirus JC. Patients with defects in cell-mediated immunity are at risk for active disease: a usually lethal demyelination of the brain. PML develops in at least 4% of patients with the acquire