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JAK/STAT signal pathway activation promotes progression and survival of human oesophageal squamous cell carcinoma

✍ Scribed by Zhenbing You; Dafu Xu; Jian Ji; Wei Guo; Weiguo Zhu; Jingdong He

Book ID: 113094813
Publisher: Springer Milan
Year: 2012
Tongue: Spanish
Weight: 453 KB
Volume: 14
Category: Article
ISSN: 1699-048X
DOI: 10.1007/s12094-012-0774-6

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## Abstract Overexpression of cyclooxygenase‐2 (COX‐2) and elevation of its derivative prostaglandin E~2~ (PGE~2~) are implicated in human esophageal squamous cell carcinoma. The expression of c‐Myc, an oncogenic transcription factor, is also upregulated in this malignant disease. This study sought