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Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma

✍ Scribed by Niwa, Yasuharu; Kanda, Hiroaki; Shikauchi, Yuko; Saiura, Akio; Matsubara, Kenichi; Kitagawa, Tomoyuki; Yamamoto, Junji; Kubo, Takahiko; Yoshikawa, Hirohide


Book ID
110069833
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
331 KB
Volume
24
Category
Article
ISSN
0950-9232

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## Abstract Aberrant janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling is involved in the oncogenesis of several cancers. Suppressors of cytokine signaling (SOCS) genes and SH2‐containing protein tyrosine phosphatase 1 (SHP1) proteins, which are negative regulator