Jak3 Is Associated with CD40 and Is Critical for CD40 Induction of Gene Expression in B Cells
โ Scribed by Silva H Hanissian; Raif S Geha
- Book ID
- 117722673
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 237 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1074-7613
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๐ SIMILAR VOLUMES
Simian immunodeficiency virus (SIV) as well as human immunodeficiency virus (HIV) induce polyclonal B-cell activation and are associated with the appearance of lymphomas in their respective hosts in either the presence or the absence of other co-infecting viruses such as Epstein-Barr virus (EBV). Ho
CD40 is a membrane glycoprotein expressed on normal and neoplastic B lymphocytes. Stimulation through CD40 regulates important cellular functions, but the effects depend on its membrane density. While extensive studies have characterized CD40 in non-Hodgkin lymphomas of immunocompetent individuals,