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CD40 activation of B-CLL cells is associated with augmented intracellular levels of CD79b and increased BCR expression in a subset of patients

✍ Scribed by Minuzzo, S; Indraccolo, S; Tosello, V; Piovan, E; Cabrelle, A; Trentin, L; Semenzato, G; Amadori, A


Book ID
110056294
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
152 KB
Volume
19
Category
Article
ISSN
0887-6924

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CD40 is a membrane glycoprotein expressed on normal and neoplastic B lymphocytes. Stimulation through CD40 regulates important cellular functions, but the effects depend on its membrane density. While extensive studies have characterized CD40 in non-Hodgkin lymphomas of immunocompetent individuals,