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JAK2 Inhibitors: Are They the Solution?

✍ Scribed by Fabio P.S. Santos; Srdan Verstovsek

Book ID
119218710
Publisher
Elsevier
Year
2011
Tongue
English
Weight
356 KB
Volume
11
Category
Article
ISSN
2152-2650

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Tyrosine kinase 2 (TYK2) is required for signaling of interleukin-23 (IL-23), which plays a key role in rheumatoid arthritis. Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1-3.