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JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis

✍ Scribed by Clara Dees; Michal Tomcik; Katrin Palumbo-Zerr; Alfiya Distler; Christian Beyer; Veronika Lang; Angelika Horn; Pawel Zerr; Jochen Zwerina; Kolja Gelse; Oliver Distler; Georg Schett; Jörg H. W. Distler


Book ID
115550464
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
728 KB
Volume
64
Category
Article
ISSN
0004-3591

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## Background: Transforming growth factor (tgf)-beta has been shown to be a potent stimulator of collagen production by fibroblasts, and could play a role in the pathogenesis of systemic sclerosis (ssc). ## Objective: To study the possible involvement of tgf-beta1 gene polymorphism in japanese pa