Autonomous induction of proliferation, J
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Astrid Bischof; Toyomichi Hara; Chia-Huey Lin; Albertus D. Beyers; Thomas Hünig
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Article
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2000
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John Wiley and Sons
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English
⚖ 139 KB
👁 1 views
Induction of proliferation in primary resting T cells requires engagement of both the antigenspecific TCR and the co-stimulatory receptor CD28. Here we report that CD28 functions as an autonomous mitogenic receptor which is mobilized by TCR signaling through cytoskeletal rearrangement. Shortcutting