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It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation

✍ Scribed by Lawrence P. Kane; Joseph Lin; Arthur Weiss


Book ID
117787257
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
865 KB
Volume
23
Category
Article
ISSN
1471-4906

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Induction of proliferation in primary resting T cells requires engagement of both the antigenspecific TCR and the co-stimulatory receptor CD28. Here we report that CD28 functions as an autonomous mitogenic receptor which is mobilized by TCR signaling through cytoskeletal rearrangement. Shortcutting