Itaconic acid production by immobilizedAspergillus terreuswith varied metal additions

✍ Scribed by Helena Kautola; Waldemar Rymowicz; Yu-Yen Linko; Pekka Linko

• Publisher: Springer
• Year: 1991
• Tongue: English
• Weight: 556 KB
• Volume: 35
• Category: Article
• ISSN: 1432-0614
• DOI: 10.1007/bf00184679

✦ Synopsis

The effect of trace and alkaline metals on itaconic acid production by polyurethane-foam-immobilized Aspergillus terreus was examined in repeated shake-flask cultures according to a statistical experimental design. An increase in the glucose or copper concentration increased the need for earth alkaline metals. The experimentally obtained highest itaconic acid concentration of 51 g/1 from 15% glucose with a total productivity of 3.67 g/1 per day was reached during the first 14-day batch fermentation. In the fourth batch the calculated highest itaconic acid concentration of 19 g/l was reached with 25% glucose, 5 g/1 of magnesium sulphate, 13 mg/1 of copper sulphate and 10 g/l of calcium chloride. The immobilization of the mycelium increased the itaconic acid concentration obtained by as much as eightfold.