✦ LIBER ✦

Issues related to the experimental design and subsequent statistical analysis of in vivo and in vitro comet studies

✍ Scribed by D.P. Lovell; G. Thomas; R. Dubow

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 112 KB
Volume: 19
Category: Article
ISSN: 0270-3211
DOI: 10.1002/(sici)1520-6866(1999)19:2<109::aid-tcm4>3.0.co;2-5

No coin nor oath required. For personal study only.

✦ Synopsis

A wide range of experimental designs are used in investigations using the Comet assay. The statistical issues associated with this assay are however not particularly unusual or difficult. It is important however to recognize that the sample rather than the cell is the experimental unit. Statistical analyses based upon measures from the individual cells can lead to serious misinterpretation of results. Interpretation of the results of the assay should be related to identifying changes of biological importance rather than relying solely on the P values of specific statistical tests.

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