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Isotype and cytotoxicity spectra of anti-lymphocyte antibodies in patients with systemic lupus erythematosus

✍ Scribed by Bruce S. Edwards; Robert P. Searles; Celestyn M. Brozek; Robyn Richards; Susan M. Savage; Hector Nolla; Charles L. Hoffman

Book ID
118374803
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
993 KB
Volume
45
Category
Article
ISSN
1090-2341

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Sera from patients with SLE frequently contain IgM and IgG antibodies with multiple specificities for lymphocyte surface determinants, including autologous antigens. The IgM antibodies are of relatively low binding avidity and exhibit broad reactivity with B and T lymphocytes from most individuals.