β Scribed by R. Bolton
No coin nor oath required. For personal study only.
This review reports recent methods by which organic compounds, and especially pharmaceuticals, have been isotopically labelled by the incorporation of carbon or hydrogen isotopes in methylation processes. Particular attention is paid to the incorporation of carbonβ11; both the synthesis of such labelled methylating agents and applications of their use are discussed. The review has reported reagents and conditions by which a number of organic compounds have been obtained recently. It also assesses the limitations of reported methods and proposes some alternative techniques and innovations.
The application of catalysts such as Ag^+^ and conditions such as microwave irradiation to encourage these reactions are also included, with suggestions of other, potentially beneficial, ways to assist them.
In many cases, the radioβchemical yield and purity of the labelled product are given along with an estimate of the total reaction time. Copyright Β© 2001 John Wiley & Sons, Ltd.
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Keywords: Methyl methacrylate / 13 C label / Mass spectrometry / 1 H NMR / 13 C NMR A synthetic scheme has been developed to prepare methyl scheme methyl (1-13 C)-and methyl (2-13 C)methacrylate (1a and 1b) have been prepared with high label incorporation methacrylate specifically 13 C-labelled at a
The \(A_{1}\) and \(E\) species fundamentals of \({ }^{12} \mathrm{CH}_{3} \mathrm{SiH}_{3},{ }^{13} \mathrm{CH}_{3} \mathrm{SiH}_{3}\), and \({ }^{12} \mathrm{CH}_{3} \mathrm{SiD}_{3}\) samples have been analyzed by gas-phase infrared spectroscopy at resolutions of up to \(0.05 \mathrm{~cm}^{-1}\).