Isothiazol-3(2H)-ones. Part 1. Synthesis, Reactions, and Biological Activity
✍ Scribed by Kathleen Taubert; Susanne Kraus; Barbel Schulze
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 50 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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📜 SIMILAR VOLUMES
## Abstract The 1,2‐dithiolosultam derivative 14 was obtained from the (__α__‐bromoalkylidene)propenesultam derivative 9 (__Scheme 1__). Regioselective cleavage of the two ester groups (→1b or 2b) allowed the preparation of derivatives with different substituents at C(3) in the dithiole ring (see 2
The isothidzok 1 is not only a dipolarophile but also a reactive and versatile dienophile: especially with oxy-substituted 'donor' 1,3-butadienes, it readily combines in Diels-Alder fashion; the regiospecificity of the addition is governed by the carbonyl group of the dienophile, whereas the sulfo g
## Abstract The synthesis of novel triaryl‐substituted 4‐(isothiazol‐3‐yl)morpholines **7** and **8**, and 1‐(isothiazol‐3‐yl)piperazines **9**–**13** by reaction of the corresponding isothiazolium salts **5** and **6** with secondary amines in the presence of __t__‐BuOK in absolute THF is describe