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Synthesis of 4-(Isothiazol-3-yl)morpholines and 1-(Isothiazol-3-yl)piperazines, and Their Inhibitory Activity towards Acetylcholinesterase

✍ Scribed by Janine Wolf; Camino M. González Tanarro; Michael Gütschow; Joachim Sieler; Bärbel Schulze

Publisher: John Wiley and Sons
Year: 2008
Tongue: German
Weight: 273 KB
Volume: 91
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.200890010

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✦ Synopsis

Abstract

The synthesis of novel triaryl‐substituted 4‐(isothiazol‐3‐yl)morpholines 7 and 8, and 1‐(isothiazol‐3‐yl)piperazines 9–13 by reaction of the corresponding isothiazolium salts 5 and 6 with secondary amines in the presence of t‐BuOK in absolute THF is described. Some representatives of the isothiazoles were evaluated as inhibitors of acetylcholinesterase from Electrophorus electricus.

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