✦ LIBER ✦

Isoquinoline–pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity

✍ Scribed by Gui-Dong Zhu; Jianchun Gong; Akiyo Claiborne; Keith W. Woods; Viraj B. Gandhi; Sheela Thomas; Yan Luo; Xuesong Liu; Yan Shi; Ran Guan; Shayna R. Magnone; Vered Klinghofer; Eric F. Johnson; Jennifer Bouska; Alexander Shoemaker; Anatol Oleksijew; Vincent S. Stoll; Ron De Jong; Tilman Oltersdorf; Qun Li; Saul H. Rosenberg; Vincent L. Giranda

Book ID: 108073988
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 175 KB
Volume: 16
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2006.03.041

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Discovery and SAR of Oxindole—Pyridine-B

Discovery and SAR of Oxindole—Pyridine-Based Protein Kinase B/Akt Inhibitors for Treating Cancers.

✍ Gui-Dong Zhu; et al. et al. 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 18 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Discovery and SAR of oxindole–pyridine-b

Discovery and SAR of oxindole–pyridine-based protein kinase B/Akt inhibitors for treating cancers

✍ Gui-Dong Zhu; Viraj B. Gandhi; Jianchun Gong; Yan Luo; Xuesong Liu; Yan Shi; Ran 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 185 KB

Adenosine-mediated activation of Akt/pro

Adenosine-mediated activation of Akt/protein kinase B in the rat hippocampus in vitro and in vivo

✍ Leon M. Gervitz; Demet Nalbant; Simon C. Williams; John C. Fowler 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 169 KB

D-501036, a novel selenophene-based trih

D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation

✍ Juang, S.-H.; Lung, C.-C.; Hsu, P.-C.; Hsu, K.-S.; Li, Y.-C.; Hong, P.-C.; Shiah 📂 Article 📅 2007 🏛 American Association for Cancer Research 🌐 English ⚖ 451 KB

Structure−Activity Relationship of 3-Sub

Structure−Activity Relationship of 3-Substituted N -(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11 H -benzo[5,6]cyclohepta[1,2- b ]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor Compounds

✍ Njoroge, F. George; Vibulbhan, Bancha; Rane, Dinananth F.; Bishop, W. Robert; Pe 📂 Article 📅 1997 🏛 American Chemical Society 🌐 English ⚖ 411 KB