Isolierung, Struktur und Synthese des Metaboliten von Azapropazon-dihydrat

✍ Scribed by G. Mixich

• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: German
• Weight: 459 KB
• Volume: 55
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19720550328

✦ Synopsis

Abstract

The renal excretion of AZAPROPAZONE‐DIHYDRATE (X) Handelsname: PROLIXAN®. Hersteller: Siegfried AG, Zofingen.

by humans was investigated. Following oral administration a new substance was detected in the urine besides X by TLC. Both compounds were separated by preparative layer chromatography and shown to be unchanged X and its hydroxylated metabolite VIII. The structure of VIII was established by chemical and spectroscopic methods (IR., NMR.) and confirmed by synthesis (Scheme 1).