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Isolation, Structure, and HIV-1 Integrase Inhibitory Activity of Xanthoviridicatin E and F, Two Novel Fungal Metabolites Produced by Penicillium chrysogenum.

✍ Scribed by Sheo B. Singh; Deborah L. Zink; Ziqiang Guan; Javier Collado; Fernando Pelaez; Peter J. Felock; Daria J. Hazuda


Publisher
John Wiley and Sons
Year
2004
Weight
72 KB
Volume
35
Category
Article
ISSN
0931-7597

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Isolation, Structure, and HIV-1 Integras
✍ Sheoβ€…B. Singh; Deborahβ€…L. Zink; Ziqiang Guan; Javier Collado; Fernando Pelaez; P πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 German βš– 112 KB πŸ‘ 1 views

## Abstract HIV‐1 Integrase is a critical enzyme for replication of HIV, and its inhibition is one of the most promising new drug targets for anti‐retroviral therapy with potentially significant advantages over existing therapies. Xanthoviridicatins E (**1**) and F (**2**) are two novel polyketide