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ChemInform Abstract: Integrastatins: Structure and HIV-1 Integrase Inhibitory Activities of Two Novel Racemic Tetracyclic Aromatic Heterocycles Produced by Two Fungal Species.

✍ Scribed by Sheo B. Singh; Deborah L. Zink; Donette S. Quamina; Fernando Pelaez; Ana Teran; Peter Felock; Daria J. Hazuda

Publisher: John Wiley and Sons
Year: 2010
Weight: 27 KB
Volume: 33
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200229234

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## Abstract HIV‐1 Integrase is a critical enzyme for replication of HIV, and its inhibition is one of the most promising new drug targets for anti‐retroviral therapy with potentially significant advantages over existing therapies. Xanthoviridicatins E (**1**) and F (**2**) are two novel polyketide