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Isolation, structure and biological activities of platensimycin B4 from Streptomyces platensis

โœ Scribed by Zhang, Chaowei; Ondeyka, John; Guan, Ziqiang; Dietrich, Lisa; Burgess, Bruce; Wang, Jun; Singh, Sheo B


Book ID
109868983
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
282 KB
Volume
62
Category
Article
ISSN
0021-8820

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Inhibition of fatty acid synthesis is emerging as a valuable target for antibacterial agents. Platensimycin and platencin are novel natural products that were reported recently to inhibit the FabF and FabF/FabH condensing enzymes, respectively, present in the fatty acid biosynthetic pathway. Selecti