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Structure of homoplatensimide A: a potential key biosynthetic intermediate of platensimycin isolated from Streptomyces platensis

โœ Scribed by Hiranthi Jayasuriya; Kithsiri B. Herath; John G. Ondeyka; Deborah L. Zink; Bruce Burgess; Jun Wang; Sheo B. Singh


Book ID
108284940
Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
118 KB
Volume
49
Category
Article
ISSN
0040-4039

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Inhibition of fatty acid synthesis is emerging as a valuable target for antibacterial agents. Platensimycin and platencin are novel natural products that were reported recently to inhibit the FabF and FabF/FabH condensing enzymes, respectively, present in the fatty acid biosynthetic pathway. Selecti