Isolation of oleanolic acid and ursolic acid from Thymus vulgaris, L.
β Scribed by Rowe, Edward J. ;Orr, Jack E. ;Uhl, A.H. ;Parks, Lloyd M.
- Publisher
- Elsevier
- Year
- 1949
- Weight
- 310 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0095-9553
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The cytotoxicity-guided fractionation of the MeOH extract of Oldenlandia diffusa (Rubiaceae) led to the isolation of ursolic acid (UA) as an active principle. Ursolic acid demonstrated a significant inhibition of the proliferation of cultured tumour cells, i.e. A549 (human lung), SK-OV-3 (ovary), SK
## Abstract Complete assignments of ^1^H and ^13^C NMR chemical shifts for oleanolic acid, 18Ξ±βoleanolic acid, ursolic acid and their 11βoxo derivatives based on ^1^H, ^13^C, 2D DQFβCOSY, NOESY, HSQC, HMBC and HSQCβTOCSY experiments were achieved. Copyright Β© 2003 John Wiley & Sons, Ltd.