## Abstract Interferon‐sensitive (745) and interferon‐resistant (3Cl‐8) Friend leukemia cells (FLC) are highly tumorigenic for DBA/2 mice. The phenotype of interferon sensitivity or resistance does not change with __in vivo__ passage. Daily administration of mouse interferon markedly enhanced the s
Isolation of interferon-resistant variants of friend erythroleukemia cells: Effects of interferon and ouabain
✍ Scribed by E. Affabris; C. Jemma; G.B. Rossi
- Book ID
- 119010451
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 1004 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0042-6822
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DBAl2 mice were injected i.v. with IFN alp-resistant 3C I 8 Friend erythroleukemia cells (FLC) which metastasize to the liver and spleen. IFN d p treatment of FLC-injected mice increased their survival time and these mice developed a resistance to a second challenge with FLC. The efficacy of IFN d p
## Abstract We have attempted to determine what host mechanisms are responsible for inducing a rapid decrease in the number of Friend leukemia cells (FLC) in the peritoneal cavity of interferon‐treated mice. By injecting radiolabelled FLC, we showed that there was a greater loss of radioactivity fr
Mouse interferon a@? exerted a similar anti-tumor effect in DBA/2 mice injected i.p. with Friend erythroleukemia cells (FLC) either sensitive or resistant to interferon as determined by both in vitro and in vivo assays. Using this tumor system we attempted to define optimal treatment regimens for in
## Abstract Administration of highly purified interferon to DA/2 mice inhibited the growth of interferon‐sensitive or interferon‐resistant Friend erythroleukemia cells implanted subcutaneously. Injection of interferon at the site of tumor inoculation was more effective than injection of interferon