Isolation of herpes simplex virus type 1 during first attack of multiple sclerosis

✍ Scribed by Dr Tomas BergstOum; Oluf Andersen; Anders Vahlne

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 332 KB
• Volume: 26
• Category: Article
• ISSN: 0364-5134
• DOI: 10.1002/ana.410260218

✦ Synopsis

Herpes simplex virus type 1 was isolated from the cerebrospinal fluid of a patient during the first attack of multiple sclerosis. This is the first virus to be isolated from the central nervous system of a living patient with MS. The virus was identified as herpes simplex virus type 1 by restriction endonuclease analysis and by an enzyme immunoassay using monoclonal antibodies. Antibodies against type 1 but not type 2 were detected in consecutive samples of serum and cerebrospinal fluid.

The patient has since entered a progressive phase of multiple sclerosis. The isolated type 1 strain might be of pathogenetic relevance to the development of multiple sclerosis in this patient. Bergstrom T, Andersen 0, Vahlne A. Isolation of herpes simplex virus type 1 during first attack of multiple sclerosis. Ann Neurol 1989;26:283-285 Although epidemiological studies on multiple sclerosis (MS) have indicated an etiological role of viral infection, attempts to isolate virus from the central nervous From the "Department of Chnical Virology, and the ?