✦ LIBER ✦

Inhibitory effects of Indonesian medicinal plants on the infection of herpes simplex virus type 1

✍ Scribed by As’ari Nawawi; Norio Nakamura; Masao Hattori; Masahiko Kurokawa; Kimiyasu Shiraki

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 63 KB
Volume: 13
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199902)13:1<37::aid-ptr382>3.0.co;2-s

No coin nor oath required. For personal study only.

✦ Synopsis

Water and methanol extracts of 30 traditional medicinal plants, collected in Indonesia, were tested for their anti HSV-1 activity. The extracts of eight plant species showed potent activity on the plaque assay at a concentration of 100 mg/mL. The therapeutic efficacy of seven selected plants was demonstrated by using a mouse HSV-1 infection assay, both the methanol extracts of the fruit of Melaleuca leucadendron (Myrtaceae) and the pericarp of Nephelium lappaceum (Sapindaceae) significantly prolonged the development of skin lesions and reduced the mortality.

📜 SIMILAR VOLUMES

Identification of ribosome-associated vi

Identification of ribosome-associated viral and cellular basic proteins during the course of infection with herpes simplex virus type 1

✍ Anna Greco; Willy Bienvenut; Jean-Charles Sanchez; Karine Kindbeiter; Denis Hoch 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 109 KB 👁 1 views

Natural resistance of BALB/c mice to her

Natural resistance of BALB/c mice to herpes simplex virus-type 1 intraperitoneal infection is abrogated by a plant extract with in vitro anti-herpes activity

✍ J. D. Claus; C. E. Coto; R. A. de Torres 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 165 KB

Adult BALB/c mice, genetically resistant to HSV-1 i.p. infection, were inoculated intraperitoneally with 1000 PFU of HSV-1 and treated by the same route with four consecutive doses of Melia azedarach L. aqueous green leaves extract (MA) each containing 80 antiviral units against HSV-1 replication in

Charaterization by two-dimensional gel e

Charaterization by two-dimensional gel electrophoresis of host proteins whose synthesis is sustained or stimulated during the course of herpes simplex virus type 1 infection

✍ Anna Greco; Niko Bausch; Yohann Couté; Jean-Jacques Diaz 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 422 KB 👁 1 views

Density functional studies on herpes sim

Density functional studies on herpes simplex virus type 1 thymidine kinase–substrate interactions: The role of Tyr-172 and Met-128 in thymine fixation

✍ F. Alber; O. Kuonen; L. Scapozza; G. Folkers; P. Carloni 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 192 KB

The enzyme herpes simplex virus type 1 thymidine kinase (HSV1 TK) salvages thymidine into the DNA metabolism of the virus. In the active site, the thymine ring of the nucleoside binds in a pocket, formed by two residues, Tyr-172 and Met-128, in a sandwich-type orientation. To investigate the nature