Isolation of herpes simplex virus clones and drug resistant mutants in microcultures
β Scribed by R. J. Klein
- Publisher
- Springer Vienna
- Year
- 1975
- Tongue
- English
- Weight
- 625 KB
- Volume
- 49
- Category
- Article
- ISSN
- 1432-8798
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## Abstract Herpes simplex virus (HSV) resistance to acyclovir or foscarnet results from mutations in viral thymidine kinase (TK) and/or DNA polymerase (pol) genes. Replication kinetics and virulence of TK and/or DNA pol clinical mutants were assessed using models of mouse encephalitis and cotton r
In this paper we report on the preliminary characterization of a mutant of herpes simplex virus type. 1 (HSV-1) selected for acycloguanosine (acyclovir, ACV) resistance in vitro. The ACV' virus was examined for a series of parameters that include chemosensitivity assay, thymidine kinase (TK) activit